![]() ![]() Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by dynamic obstruction of the left ventricular (LV) outflow tract (LVOT). Originally published of the American Heart Association. ![]() These findings suggest that measures of 3D strain may have prognostic value among patients with left bundle-branch block. A higher 2D global longitudinal strain was independently associated with LVEF maintenance among patients with preserved LVEF at baseline (OR, 0.65), whereas a lower 3D global circumferential strain was predictive of persistently reduced LVEF among those with reduced LVEF at baseline (OR, 0.61). In this retrospective analysis involving 290 patients with left bundle-branch block, 14.9% of those with a baseline LVEF ≥40% progressed to LV dysfunction after a median follow-up period of 29.1 months and 51.0% of those with a baseline LVEF <40% had improved LV function. However, the predictive value of 3-dimensional (3D) speckle-tracking echocardiography has not yet been investigated in these patients. Previous studies have demonstrated that 2-dimensional (2D) global longitudinal strain (GLS) is associated with cardiovascular outcomes in patients with left bundle-branch block. This patient-level meta-analysis shows the improved outcomes of patients with IVCD and suggests reconsidering the current practice of aggregating patients with HF in a “non-LBBB category” when selecting candidates for CRT. The results showed that CRT was associated with a lower risk of the primary and secondary endpoints in patients with QRS ≥150 ms and either LBBB or IVCD but not in those with right bundle branch block. ![]() The primary endpoint was time to HF hospitalization or death, and the secondary endpoint was time to all-cause death. Using a Bayesian Weibull survival regression model, the continuous relationship between QRS duration and CRT benefit was also examined within subgroups (left bundle branch block, right bundle branch block, and intraventricular conduction delay ). This study analyzed patient-level data from eight pivotal randomized clinical trials of cardiac resynchronization therapy (CRT) in patients with heart failure (HF) to assess the benefit of CRT by QRS characteristics. Benefit from cardiac resynchronization therapy (CRT) varies by QRS characteristics individual randomized trials are underpowered to assess benefit for relatively small subgroups. ![]()
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